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Article

Tumor necrosis factor-beta is associated with thymic apoptosis during acute rejection.

Transplantation - 15 Oct 1998

Yamaguchi Y, Okabe K, Miyanari N, Matsumura F, Ichiguchi O, Akizuki E, Matsuda T, Liang J, Ohshiro H, Miyayama Y, Yamada S, Mori K, Ogawa M

Abstract excerpt

BACKGROUND: Intrathymic events undergoing allograft rejection remain undefined. The present study investigated the role of tumor necrosis factor-beta on acute thymic involution in rat hepatic allograft recipients during rejection. METHODS: Apoptosis and cellular phenotypic changes in the thymus were studied after hepatic transplantation. RESULTS: Thymocytes in both the medulla and cortex were sparse during acute...

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PMID: 9798700
DOI: 10.1097/00007890-199810150-00014

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