Article
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation.
mAbs - 1 Oct 2018
Rodriguez-Barbosa J I, Ferreras M C, Buhler L, Jones N D, Schneider P, Perez-Simon J A, Del Rio M L
Abstract excerpt
Natural killer (NK) cells are a population of innate type I lymphoid cells essential for early anti-viral responses and are known to modulate the course of humoral and cellular-mediated T cell responses. We assessed the role of NK cells in allogeneic CD8 T cell-mediated responses in an immunocompetent mouse model across an MHC class I histocompatibility barrier to determine its impact in therapeutic clinical...
Topics
- Animals
- Antigen Presentation
- CD8-Positive T-Lymphocytes
- Cells, Cultured
- Cytotoxicity, Immunologic
- Graft Rejection
- Histocompatibility Antigens Class I
- Humans
- Isoantigens
- Killer Cells, Natural
- Lymphocyte Depletion
- Mice
- Mice, Inbred C57BL