Article
Differential Impact of T-bet and IFNγ on Pancreatic Islet Allograft Rejection.
Transplantation - 1 Sept 2018
Besançon Alix, Demir Zeynep, Goncalves Tania, Valette Fabrice, Panafieu Emilie, Chatenoud Lucienne, You Sylvaine
Abstract excerpt
BACKGROUND: T cell-mediated graft rejection is mostly correlated with potent Th1 responses. However, because IFNγ mice reject their graft as efficiently as wild-type (WT) mice, the exact contribution of IFNγ and its transcription factor T-bet remains a matter of debate. Here, we address this question in the context of pancreatic islet allograft to better inform the molecular pathways that hampers islet survival...
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