Article

Transgenerational inheritance of betaine-induced epigenetic alterations in estrogen-responsive IGF-2/IGFBP2 genes in rat hippocampus

2019-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Betaine as a methyl donor participates in DNA methylation. Here, we sought to investigate the effects of betaine on hippocampal expression of neurogenesis genes and their DNA methylation status across three generations. Pregnant rats (F0) were fed control and betaine-supplemented diets throughout gestation and lactation; and female F1 and F2 offspring at weaning, together with the F0 dams, were...

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Literature Corpus work: 4237e425-27d8-5ca3-a23d-fd95b059a9ff
DOI: 10.1101/640524

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