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Article

Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2017

Tserga Aggeliki, Binder Alexandra M, Michels Karin B

Abstract excerpt

Folic acid is an essential component of 1-carbon metabolism, which generates methyl groups for DNA methylation. Disruption of genomic imprinting leads to biallelic expression which may affect disease susceptibility possibly reflected in high levels of S-adenosyl-homocysteine (SAH) and low levels of S-adenosyl-methionine (SAM). We investigated the association between folic acid supplementation during pregnancy and...

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Share to DNA Methylation
Share to Epigenomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Genomic Imprinting

Share to Insulin-Like Growth Factor II

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Open in PubMed Open full text

Identifiers

PMID: 28778973
DOI: 10.1096/fj.201601214RR
PMCID: PMC5690385

Genes

IGF2
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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