Article
In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific.
The Journal of nutrition - 1 Aug 2002
Choumenkovitch Silvina F, Selhub Jacob, Bagley Pamela J, Maeda Nobuyo, Nadeau Marie R, Smith Donald E, Choi Sang-Woon
Abstract excerpt
The cystathionine beta-synthase knockout mouse provides a unique opportunity to study biochemical consequences of a defective cystathionine beta-synthase enzyme. The present study was undertaken to assess the effect of elevated plasma total homocysteine caused by cystathionine beta-synthase deficiency on one-carbon metabolism in 10 homozygous mutant mice and 10 age- and sex-matched wild-type mice. Plasma total...
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