Article
Molecular signature of disease onset in granulin mutation carriers: a gene expression analysis study.
Neurobiology of aging - 1 Jul 2013
Milanesi Elena, Bonvicini Cristian, Alberici Antonella, Pilotto Andrea, Cattane Nadia, Premi Enrico, Gazzina Stefano, Archetti Silvana, Gasparotti Roberto, Cancelli Vanessa, Gennarelli Massimo, Padovani Alessandro, Borroni Barbara
Abstract excerpt
Mutations within Granulin (GRN) gene are causative of autosomal dominant frontotemporal lobar degeneration (FTLD). Though GRN mutations are inherited at birth, the disease onset usually occurs in the sixth decade of life. The objective of this study was to identify new genetic pathways linked to inherited GRN disease and involved in the shift from asymptomatic to symptomatic stages. Microarray gene expression...
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