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Article

Association between tumor necrosis factor-α (TNF-α) promoter -308 G/A and response to TNF-α blockers in rheumatoid arthritis: a meta-analysis.

Modern rheumatology - 1 May 2013

Zeng Zhen, Duan Zhenhua, Zhang Tianchen, Wang Sheng, Li Guixing, Gao Jing, Ye Dongqing, Xu Shengqian, Xu Jianhua, Zhang Li, Pan Faming

Abstract excerpt

OBJECTIVES: Tumor necrosis factor (TNF)-α promoter -308G/A polymorphism has been shown to be associated with high TNF-α production and poor response to anti-TNF-α treatment. However, not all patients show a good response to TNF-α antagonists, so this association remains controversial. This study was designed to investigate whether TNF-α promoter -308 G/A polymorphism is associated with responsiveness to anti-TNF...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22760475
DOI: 10.1007/s10165-012-0699-5

Genes

TNF
ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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