Article
Association between tumor necrosis factor-α (TNF-α) promoter -308 G/A and response to TNF-α blockers in rheumatoid arthritis: a meta-analysis.
Modern rheumatology - 1 May 2013
Zeng Zhen, Duan Zhenhua, Zhang Tianchen, Wang Sheng, Li Guixing, Gao Jing, Ye Dongqing, Xu Shengqian, Xu Jianhua, Zhang Li, Pan Faming
Abstract excerpt
OBJECTIVES: Tumor necrosis factor (TNF)-α promoter -308G/A polymorphism has been shown to be associated with high TNF-α production and poor response to anti-TNF-α treatment. However, not all patients show a good response to TNF-α antagonists, so this association remains controversial. This study was designed to investigate whether TNF-α promoter -308 G/A polymorphism is associated with responsiveness to anti-TNF...
Topics
- Alleles
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Humans
- Pharmacogenetics
- Promoter Regions, Genetic
- Severity of Illness Index
- Treatment Outcome
- Tumor Necrosis Factor-alpha