Article
IL2RA genetic variants reduce IL-2-dependent responses and aggravate human cutaneous leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2015
Oliveira Pablo R S, Dessein Hélia, Romano Audrey, Cabantous Sandrine, de Brito Maria E F, Santoro Ferrucio, Pitta Maira G R, Pereira Valéria, Pontes-de-Carvalho Lain C, Rodrigues Virmondes, Rafati Sima, Argiro Laurent, Dessein Alain J
Abstract excerpt
The outcome of Leishmania infections varies substantially, depending on the host and the parasite strain; infection may be asymptomatic or cause mild or severe skin ulcers (cutaneous leishmaniasis [CL]), limited or disseminated lesions, or lethal visceral disease. We previously reported an association between IL-2R mutations and susceptibility to visceral leishmaniasis in children infected with Leishmania...
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