SNPs at the IL-2, IL-12, TNF-α and TGF-β1 regulatory gene regions are probably important for Toxoplasma gondii congenital transmission and disease severity in humans.

doi:10.1016/j.micinf.2025.105565

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SNPs at the IL-2, IL-12, TNF-α and TGF-β1 regulatory gene regions are probably important for Toxoplasma gondii congenital transmission and disease severity in humans.

Microbes and infection - 1 Jan 2025

Rico-Torres Claudia P, Reyes-León Adriana, Figueroa-Damián Ricardo, Vela-Amieva Marcela, Macias-Parra Mercedes, Ruiz-García Matilde, Bosch-Canto Vanessa, Gómez-Chávez Fernando, Ortiz-Alegría Luz Belinda, Cañedo-Solares Irma, Saltigeral-Simentel Patricia, Ordaz-Favila Juan Carlos, Escobedo-Torres Mónica Patricia, Sánchez-Pérez Carmen, López-Candiani Carlos, Rivera-González Ivan Rolando, Hernández-Antunez Blanca Gloria, Hernández-Delgado Lorena, Luna-Pastén Héctor, Vargas-Villavicencio José A, Correa Dolores

Abstract excerpt

Toxoplasma gondii infection in pregnant females can cause congenital toxoplasmosis. Although maternal and infant immune profiles appear to play a role, studies on this topic are scarce. We analyzed SNPs in the regulatory regions of cytokine genes in 30 mother-newborn pairs, five mothers and two infants with known status, with respect to vertical transmission and the clinical outcome of those infected....

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PMID: 41072754
DOI: 10.1016/j.micinf.2025.105565

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