Article
Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006
Frodsham Angela J, Zhang Lyna, Dumpis Uga, Taib Nor Azizah Mohd, Best Steve, Durham Andrew, Hennig Branwen J W, Hellier Simon, Knapp Susanne, Wright Mark, Chiaramonte Maria, Bell John I, Graves Mary, Whittle Hilton C, Thomas Howard C, Thursz Mark R, Hill Adrian V S
Abstract excerpt
Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in approximately 350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a...
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