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Article

Association of TNFRSF1B Promoter Polymorphisms with Human Disease: Further Studies Examining T-Regulatory Cells Are Required.

Frontiers in immunology - 1 Jan 2018

Li Hongchuan, Anderson Stephen K

Abstract excerpt

The TNFR2 receptor is expressed by highly active regulatory T cells, and thus constitutes an important therapeutic target for the treatment of autoimmune disease and cancer. Disease susceptibility as well as the potential response to therapies directed at TNFR2 could be significantly impacted by genetic variation in the promoter of the TNFRSF1B gene that codes for the TNFR2 protein. To date, only a few studies...

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Identifiers

PMID: 29559979
DOI: 10.3389/fimmu.2018.00443
PMCID: PMC5845690

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