<scp>ROS</scp>‐generating oxidases <scp>N</scp>ox1 and <scp>N</scp>ox4 contribute to oncogenic <scp>R</scp>as‐induced premature senescence

Abstract excerpt

Activated oncogenes induce premature cellular senescence, a permanent state of proliferative arrest in primary rodent and human fibroblasts. Recent studies suggest that generation of reactive oxygen species (ROS) is involved in oncogenic Ras-induced premature senescence. However, the signaling mechanism controlling this oxidant-mediated irreversible growth arrest is not fully understood. Here, we show that...

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