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Article

The impact of oncogenic RAS on redox balance and implications for cancer development.

Cell death & disease - 18 Dec 2019

Lim Jonathan K M, Leprivier Gabriel

Abstract excerpt

The RAS family of proto-oncogenes comprises HRAS, KRAS, and NRAS, which are among the most mutated genes in human cancers. The RAS family genes encode small GTPases that coordinate key signaling pathways in response to growth factors. Mutations in RAS result in a constitutively active form of the protein that supports cellular transformation and tumorigenesis. The mechanisms of oncogenic RAS-mediated...

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Identifiers

PMID: 31852884
DOI: 10.1038/s41419-019-2192-y
PMCID: PMC6920345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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