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Article

KLF4 inhibited the senescence-associated secretory phenotype in ox-LDL-treated endothelial cells via PDGFRA/NAMPT/mitochondrial ROS.

Aging - 8 May 2024

Ding Haoran, Tong Jing, Lin Hao, Ping Fan, Yao Tongqing, Ye Zi, Chu Jiapeng, Yuan Deqiang, Wang Kangwei, Liu Xuebo, Chen Fei

Abstract excerpt

BACKGROUND: Inflammation is one of the significant consequences of ox-LDL-induced endothelial cell (EC) dysfunction. The senescence-associated secretory phenotype (SASP) is a critical source of inflammation factors. However, the molecular mechanism by which the SASP is regulated in ECs under ox-LDL conditions remains unknown. RESULTS: The level of SASP was increased in ox-LDL-treated ECs, which could be augmented...

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Identifiers

PMID: 38728249
DOI: 10.18632/aging.205805
PMCID: PMC11132013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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