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Article

Importance of genetics in chronic lymphocytic leukemia.

Blood reviews - 1 May 2011

Zenz Thorsten, Mertens Daniel, Döhner Hartmut, Stilgenbauer Stephan

Abstract excerpt

Recurrent losses or gains of genomic material as well as mutations of key tumor suppressors (ATM and TP53) have been identified in chronic lymphocytic leukemia (CLL). These aberrations are important "drivers" of the disease and some of its clinical characteristics. There is a remarkable heterogeneity in the clinical course between patient subgroups with distinct genetic features. While some mutations are...

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Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 17
Share to Chronic Lymphocytic Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Translocation, Genetic

Source

Identifiers

PMID: 21435757
DOI: 10.1016/j.blre.2011.02.002

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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