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Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch

9 Nov 2018

Abstract excerpt

Protein ubiquitination is an important means of post-translational modification which plays an essential role in the regulation of various aspects of leukocyte development and function. The specificity of ubiquitin tagging to a protein substrate is determined by E3 ubiquitin ligases via defined E3-substrate interactions. In this review, we will focus on two E3 ligases, VHL and Itch, to discuss the latest progress...

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PMID: 30413999
DOI: 10.1007/s13238-018-0586-8

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