Article
The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17.
Genetics - 1 May 2010
Hassemer E L, Le Gall S M, Liegel R, McNally M, Chang B, Zeiss C J, Dubielzig R D, Horiuchi K, Kimura T, Okada Y, Blobel C P, Sidjanin D J
Abstract excerpt
The waved with open eyes (woe) locus is a spontaneous recessive mouse mutation that exhibits wavy fur, eyelids open at birth, and enlarged heart and esophagus. In this study, we confirmed the previously identified woe phenotypes and additionally identified anterior eye segment defects, absence of the meibomian glands, and defects in the semilunar cardiac valves. Positional cloning identified a C794T substitution...
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