Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional variant in the MTOR promoter modulates its expression and is associated with renal cell cancer risk.

PloS one - 1 Jan 2012

Cao Qiang, Ju Xiaobing, Li Pu, Meng Xiaoxin, Shao Pengfei, Cai Hongzhou, Wang Meilin, Zhang Zhengdong, Qin Chao, Yin Changjun

Abstract excerpt

BACKGROUND: The mTOR signaling pathway plays a crucial role in the carcinogenesis of renal cell cancer (RCC). We sought to investigate the influence of genetic variations in the mTOR pathway-related genes on the risk of RCC. METHODS: We genotyped 8 potentially functional polymorphisms in AKT1, AKT2, PTEN and MTOR genes using the TaqMan method in a case-control study of 710 RCC patients and 760 cancer-free...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Neoplasms

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Regression Analysis

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 23209702
DOI: 10.1371/journal.pone.0050302
PMCID: PMC3508984

Genes

MTOR
PTEN
AKT1
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional variant in the MTOR promoter modulates its expression and is associated with renal cell cancer risk.PMID 23209702Read ↗

Genetic variants in the mTOR pathway with renal cancer risk and subtypes in East Indian population.Semantic proximity Read ↗

Functional promoter rs2295080 T>G variant in MTOR gene is associated with risk of colorectal cancer in a Chinese population.Semantic proximity Read ↗

Energy balance, polymorphisms in the mTOR pathway, and renal cell carcinoma risk.Semantic proximity Read ↗

Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population.Semantic proximity Read ↗

Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.Semantic proximity Read ↗

Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis.Semantic proximity Read ↗

A polymorphism (rs2295080) in mTOR promoter region and its association with gastric cancer in a Chinese population.Semantic proximity Read ↗

Association of mTOR polymorphisms with cancer risk and clinical outcomes: a meta-analysis.Semantic proximity Read ↗

Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk.Semantic proximity Read ↗

Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk.Semantic proximity Read ↗

Impacts of the mTOR gene polymorphisms rs2536 and rs2295080 on breast cancer risk in the Chinese population.Semantic proximity Read ↗

In silico comprehensive analysis of coding and non-coding SNPs in human mTOR protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.