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Article

In silico comprehensive analysis of coding and non-coding SNPs in human mTOR protein.

PloS one - 1 Jan 2022

Yasmin Tahirah

Abstract excerpt

The mammalian/mechanistic target of rapamycin (mTOR) protein is an important growth regulator and has been linked with multiple diseases including cancer and diabetes. Non-synonymous mutations of this gene have already been found in patients with renal clear cell carcinoma, melanoma, and acute lymphoid leukemia among many others. Such mutations can potentially affect a protein's structure and hence its functions....

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PMID: 35788771
DOI: 10.1371/journal.pone.0270919
PMCID: PMC9255762

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