A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.

doi:10.1016/j.jaci.2014.04.011

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Article

A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.

The Journal of allergy and clinical immunology - 1 Nov 2014

Sharma Sunita, Zhou Xiaobo, Thibault Derek M, Himes Blanca E, Liu Andy, Szefler Stanley J, Strunk Robert, Castro Mario, Hansel Nadia N, Diette Gregory B, Vonakis Becky M, Adkinson N Franklin, Avila Lydiana, Soto-Quiros Manuel, Barraza-Villareal Albino, Lemanske Robert F, Solway Julian, Krishnan Jerry, White Steven R, Cheadle Chris, Berger Alan E, Fan Jinshui, Boorgula Meher Preethi, Nicolae Dan, Gilliland Frank, Barnes Kathleen, London Stephanie J, Martinez Fernando, Ober Carole, Celedón Juan C, Carey Vincent J, Weiss Scott T, Raby Benjamin A

Abstract excerpt

BACKGROUND: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing. OBJECTIVE: We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a...

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Identifiers

PMID: 24934276
DOI: 10.1016/j.jaci.2014.04.011
PMCID: PMC4253878

Genes

FADS2
NAGA
GSDMB
ORMDL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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