Article
Cell-type-specific and disease-associated expression quantitative trait loci in the human lung.
Nature genetics - 1 Apr 2024
Natri Heini M, Del Azodi Christina B, Peter Lance, Taylor Chase J, Chugh Sagrika, Kendle Robert, Chung Mei-I, Flaherty David K, Matlock Brittany K, Calvi Carla L, Blackwell Timothy S, Ware Lorraine B, Bacchetta Matthew, Walia Rajat, Shaver Ciara M, Kropski Jonathan A, McCarthy Davis J, Banovich Nicholas E
Abstract excerpt
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the mechanisms through which genetic variation influences complex traits and disease pathobiology. To this end, we performed single-cell RNA sequencing of lung tissue from 66...
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