Loss of the chromatin remodeler, <i>ATRX</i> , promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

Abstract excerpt

Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypic changes correspond with activation of NF-κB signaling, extracellular matrix remodeling, increased integrin αvβ3 expression, and ETS family transcription factor...

Topics

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• alpha-Thalassemia
• Chromatin Assembly and Disassembly
• Chromatin Remodeling and Cancer
• Genetics and Neurodevelopmental Disorders
• Glioma Diagnosis and Treatment
• Telomere Homeostasis
• X-Linked Intellectual Disability
• X-linked Nuclear Protein

Identifiers and source

Literature Corpus work

58ede576-d528-5bfa-a1dc-570aa5427236

DOI

10.1101/2022.04.22.489086