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Article

The role of β-arrestins in cancer.

Progress in molecular biology and translational science - 1 Jan 2013

Sobolesky Philip Michael, Moussa Omar

Abstract excerpt

Beyond their well-characterized roles in G protein-coupled receptor desensitization and trafficking, β-arrestins (ARRBs) have been implicated in the regulation of several basic cellular functions, including cell cycle regulation, cell migration, and apoptotic signaling. Nowhere are the data supporting a physiologically relevant role for these arrestin-mediated responses stronger than in cancer. In vitro, ARRBs...

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PMID: 23764062
DOI: 10.1016/B978-0-12-394440-5.00015-2

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