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Article

The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation.

Developmental biology - 1 Feb 2013

Hossain Mahmud, Ahmed Giasuddin, Naser Iftekhar Bin, Shinmyo Yohei, Ito Ayako, Riyadh M Asrafuzzaman, Felemban Athary, Song Xiaohong, Ohta Kunimasa, Tanaka Hideaki

Abstract excerpt

We have shown that draxin is a repulsive axon guidance molecule for a variety of neuron classes and that genetic deletion of draxin in mice results in the absence of all forebrain commissures. Moreover, we also identified a secreted molecule, Tsukushi (TSK), that belongs to the small leucine-rich proteoglycan family (SLRP) and inhibits signaling molecules, such as BMP and Wnt. TSK knockout mice show malformation...

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Identifiers

PMID: 23206892
DOI: 10.1016/j.ydbio.2012.11.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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