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Article

Draxin Inhibits Axonal Outgrowth through the Netrin Receptor DCC

28 Sept 2011

Abstract excerpt

Draxin, a recently identified axon guidance protein, is essential for the formation of forebrain commissures, and can mediate repulsion of netrin-stimulated spinal commissural axons. Here, we report that draxin binds multiple netrin receptors: DCC (deleted in colorectal cancer), Neogenin, UNC5s (H1, H2, H3), and DSCAM (Down's syndrome cell adhesion molecule). Since draxin and Dcc knockouts showed similar...

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Identifiers

PMID: 21957262
DOI: 10.1523/jneurosci.0943-11.2011

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