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Article

β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model.

American journal of respiratory cell and molecular biology - 1 Feb 2013

Thanawala Vaidehi J, Forkuo Gloria S, Al-Sawalha Nour, Azzegagh Zoulikha, Nguyen Long P, Eriksen Jason L, Tuvim Michael J, Lowder Thomas W, Dickey Burton F, Knoll Brian J, Walker Julia K L, Bond Richard A

Abstract excerpt

β(2)-Adrenoceptor (β2AR) agonists are the most effective class of bronchodilators and a mainstay of asthma management. The first potent β2AR agonist discovered and widely used in reversing the airway constriction associated with asthma exacerbation was the endogenous activator of the β2AR, epinephrine. In this study, we demonstrate that activation of the β2AR by epinephrine is paradoxically required for...

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Identifiers

PMID: 23204390
DOI: 10.1165/rcmb.2012-0364OC
PMCID: PMC3604060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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