Article
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model.
Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009
Nguyen Long P, Lin Rui, Parra Sergio, Omoluabi Ozozoma, Hanania Nicola A, Tuvim Michael J, Knoll Brian J, Dickey Burton F, Bond Richard A
Abstract excerpt
Chronic regular use of beta(2)-adrenoceptor (beta(2)-AR) agonists in asthma is associated with a loss of disease control and increased risk of death. Conversely, we have found that administration of beta(2)-AR inverse agonists results in attenuation of the asthma phenotype in an allergen-driven murine model. Besides antagonizing agonist-induced signaling and reducing signaling by empty receptors, beta-AR inverse...
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