Blocking mechanical airway epithelia damage during asthma progression reverses airway remodelling and hyperresponsiveness

Abstract excerpt

Airway smooth muscle (ASM) hyperresponsiveness is the defining feature of asthma, yet neither its origins nor the processes that establish and maintain it are understood. Here, using a mouse model, we show that hyperresponsiveness arises from ASM realignment into dense, parallel bundles reinforced by excess extracellular matrix, a fundamental remodelling rather than mere amplification of existing contractile ASM....

Topics

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• Airway Remodeling
• Asthma
• Bronchial Hyperreactivity
• Inflammation
• Lung
• Models, Biological
• Phenotype
• Severity of Illness Index

Identifiers and source

Literature Corpus work

3741912f-43c4-595f-9c6a-c71b58128669

DOI

10.1101/2025.11.10.687569