Article
Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing.
The Journal of infectious diseases - 15 Feb 2013
Dingle Kate E, Didelot Xavier, Ansari M Azim, Eyre David W, Vaughan Alison, Griffiths David, Ip Camilla L C, Batty Elizabeth M, Golubchik Tanya, Bowden Rory, Jolley Keith A, Hood Derek W, Fawley Warren N, Walker A Sarah, Peto Timothy E, Wilcox Mark H, Crook Derrick W
Abstract excerpt
BACKGROUND: Clostridium difficile is a major cause of nosocomial diarrhea, with 30-day mortality reaching 30%. The cell surface comprises a paracrystalline proteinaceous S-layer encoded by the slpA gene within the cell wall protein (cwp) gene cluster. Our purpose was to understand the diversity and evolution of slpA and nearby genes also encoding immunodominant cell surface antigens. METHODS: Whole-genome...
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