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Article

Surface-layer protein A (SlpA) is a major contributor to host-cell adherence of Clostridium difficile.

PloS one - 1 Jan 2013

Merrigan Michelle M, Venugopal Anilrudh, Roxas Jennifer L, Anwar Farhan, Mallozzi Michael J, Roxas Bryan A P, Gerding Dale N, Viswanathan V K, Vedantam Gayatri

Abstract excerpt

Clostridium difficile is a leading cause of antibiotic-associated diarrhea, and a significant etiologic agent of healthcare-associated infections. The mechanisms of attachment and host colonization of C. difficile are not well defined. We hypothesize that non-toxin bacterial factors, especially those facilitating the interaction of C. difficile with the host gut, contribute to the initiation of C. difficile...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24265687
DOI: 10.1371/journal.pone.0078404
PMCID: PMC3827033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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