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Article

Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions.

Viruses - 6 Nov 2012

Moreno Héctor, Grande-Pérez Ana, Domingo Esteban, Martín Verónica

Abstract excerpt

Lymphocytic choriomeningitis virus (LCMV) has contributed to unveil some of the molecular mechanisms of lethal mutagenesis, or loss of virus infectivity due to increased mutation rates. Here we review these developments, and provide additional evidence that ribavirin displays a dual mutagenic and inhibitory activity on LCMV that can be relevant to treatment designs. Using 5-fluorouracil as mutagenic agent and...

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Share to Antiviral Agents
Share to Drug Therapy, Combination
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocytic choriomeningitis virus

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Source

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Identifiers

PMID: 23202505
DOI: 10.3390/v4112786
PMCID: PMC3509673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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