Article
Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet.
Biochemical and biophysical research communications - 4 Jan 2013
Lo Yuan-Hung, Ho Po-Chun, Chen Min-Shan, Hugo Eric, Ben-Jonathan Nira, Wang Shao-Chun
Abstract excerpt
Clonal proliferation is an obligatory component of adipogenesis. Although several cell cycle regulators are known to participate in the transition between pre-adipocyte proliferation and terminal adipocyte differentiation, how the core DNA synthesis machinery is coordinately regulated in adipogenesis remains elusive. PCNA (Proliferating Cell Nuclear Antigen) is an indispensable component for DNA synthesis during...
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