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Article

Molecular dynamics simulations and bioinformatics' analysis of deleterious missense single nucleotide polymorphisms in Glyoxalase-1 gene.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Syed Nida Ali, Bhatti Attya, John Peter

Abstract excerpt

Glyoxalase-1 (Glo-1) is a key member of the Glyoxalase system, the primary line of defense against dicarbonyl stress which, in tandem, with reduced levels of expression or activity of Glyoxalase-1 enzyme, has been implicated in various human diseases like type 2 diabetes mellitus (T2DM) and its vascular complications. The association of Glo-1 single nucleotide polymorphisms with genetic susceptibility to T2DM and...

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PMID: 36812296
DOI: 10.1080/07391102.2023.2181654

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