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Article

GLO1 gene polymorphisms and their association with retinitis pigmentosa: a case-control study in a Sicilian population.

Molecular biology reports - 1 Oct 2018

Donato Luigi, Scimone Concetta, Nicocia Giacomo, Denaro Lucia, Robledo Renato, Sidoti Antonina, D'Angelo Rosalia

Abstract excerpt

Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme involved in detoxification of methylglyoxal (MGO), a cytotoxic byproduct of glycolysis, whose excess can cause oxidative stress. In retinitis pigmentosa (RP), the prevalent cause of blindness just during working life in the industrialized countries, oxidative stress represents one of the possible mechanisms leading to death of cones following that of rods in the...

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Source

Identifiers

PMID: 30099685
DOI: 10.1007/s11033-018-4295-4

Genes

GLO1
RPE

Variants

rs1130534
rs1049346
rs2736654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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