Article
Megakaryocytic and erythrocytic lineages share specific transcription factors.
Nature - 29 Mar 1990
Romeo P H, Prandini M H, Joulin V, Mignotte V, Prenant M, Vainchenker W, Marguerie G, Uzan G
Abstract excerpt
Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage. NF-E1 expression seems to be restricted to the erythrocytic lineage. A closely related (if not identical) protein is found...
Topics
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- DNA-Binding Proteins
- Endopeptidase K
- Erythrocytes
- Erythroid-Specific DNA-Binding Factors
- Gene Expression
- Hematopoietic Stem Cells
- Humans
- Megakaryocytes
- Mutation
- NF-E2 Transcription Factor
- NF-E2 Transcription Factor, p45 Subunit
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- RNA, Messenger