Article
Megakaryocytic and erythrocytic lineages share specific transcription factors.
Nature - 29 Mar 1990
Romeo P H, Prandini M H, Joulin V, Mignotte V, Prenant M, Vainchenker W, Marguerie G, Uzan G
Abstract excerpt
Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage. NF-E1 expression seems to be restricted to the erythrocytic lineage. A closely related (if not identical) protein is found in both a human megakaryocytic cell line and purified human megakaryocytes; it binds to promoter regions of two...
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