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Article

EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation

3 Jun 2008

Abstract excerpt

Previous observations suggested that functional antagonism between FLI-1 and EKLF might be involved in the commitment toward erythrocytic or megakaryocytic differentiation. We show here, using inducible shRNA expression, that EKLF knockdown in mouse erythroleukemia (MEL) cells decreases erythrocytic and increases megakaryocytic as well as Fli-1 gene expression. Chromatin immunoprecipitation analyses revealed that...

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PMID: 18523154
DOI: 10.1182/blood-2007-07-098996

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EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiationPMID 18523154Read ↗

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Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cellsSemantic proximity Read ↗

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GPS2 promotes erythroid differentiation by control of the stability of EKLF proteinSemantic proximity Read ↗

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.Semantic proximity Read ↗

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FLI-1 is a suppressor of erythroid differentiation in human hematopoietic cellsSemantic proximity Read ↗

Erythroid Kruppel‐like factor (EKLF) is recruited to the <i>γ</i>‐<i>globin</i> gene promoter as a co‐activator and is required for <i>γ</i>‐<i>globin</i> gene induction by short‐chain fatty acid derivativesSemantic proximity Read ↗

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