Expression of Transcription Factors during Megakaryocytic Differentiation of CD34+ Cells from Human Cord Blood Induced by Thrombopoietin

Abstract excerpt

Although normal megakaryocytic development has been shown to require the presence of functional GATA-1 and NF-E2 transcription factors in vivo, the roles of other members of the GATA binding factors and NF-E2 family during megakaryocytic differentiation are unclear. the present study, the expression of GATA family members, GATA-1 and GATA-2, a GATA-binding factor, EVI-1, the large subunit of NF-E2 factor, p45 and...

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