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Article

Biomarkers and novel therapeutic targets in gastrointestinal stromal tumors (GISTs).

Recent patents on anti-cancer drug discovery - 1 Sept 2013

Campanella Nathália C, de Oliveira António T, Scapulatempo-Neto Cristovam, Guimarães Denise P, Reis Rui M

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) owe their development to the activating mutations in mast/stem cell growth factor receptor (KIT) or platelet-derived growth factor receptor A (PDGFRA) oncogenes. Both these KIT and PDGFRA oncogenes are members of the type III transmembrane receptor tyrosine kinase family that stimulates intracellular signaling pathways controlling cell proliferation, adhesion, apoptosis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23198834
DOI: 10.2174/15748928113089990030

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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