Article
Gastrointestinal stromal tumor: a review of current and emerging therapies.
Cancer metastasis reviews - 1 Jun 2021
Al-Share Bayan, Alloghbi Abdulrahman, Al Hallak Mohammed Najeeb, Uddin Hafiz, Azmi Asfar, Mohammad Ramzi M, Kim Steve H, Shields Anthony F, Philip Philip A
Abstract excerpt
Gastrointestinal stromal tumors (GIST) are rare neoplasms arising from the interstitial cell of Cajal in the gastrointestinal tract. Two thirds of GIST in adult patients have c-Kit mutation and smaller fractions have platelet derived growth factor receptor alpha (PDGFRA) mutation. Surgery is the only curative treatment for localized disease. Imatinib improves survival when used adjuvantly and in advanced disease....
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