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Article

Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34.

Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2012

Kasmapour Bahram, Gronow Achim, Bleck Christopher K E, Hong Wanjin, Gutierrez Maximiliano Gabriel

Abstract excerpt

Phagosome maturation is an essential part of the innate and adaptive immune response. Although it is well established that several Ras-related proteins in brain (Rab) proteins become associated to phagosomes, little is known about how these phagosomal Rab proteins influence phagosome maturation. Here, we show a specific role for Rab34 and mammalian uncoordinated 13-2 (Munc13-2) in phagolysosome biogenesis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23197834
DOI: 10.1073/pnas.1206811109
PMCID: PMC3528610

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