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Article

Mycobacterium's arrest of phagosome maturation in macrophages requires Rab5 activity and accessibility to iron.

Molecular biology of the cell - 1 Aug 2003

Kelley Victoria A, Schorey Jeffrey S

Abstract excerpt

Many mycobacteria are intramacrophage pathogens that reside within nonacidified phagosomes that fuse with early endosomes but do not mature to phagolysosomes. The mechanism by which mycobacteria block this maturation process remains elusive. To gain insight into whether fusion with early endosomes is required for mycobacteria-mediated inhibition of phagosome maturation, we investigated how perturbing the GTPase...

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Share to Bone Marrow Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium avium

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Identifiers

PMID: 12925769
DOI: 10.1091/mbc.e02-12-0780
PMCID: PMC181573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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