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Article

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.

The EMBO journal - 15 Oct 2020

Liu Zhiyong, Xu Enquan, Zhao Hien Tran, Cole Tracy, West Andrew B

Abstract excerpt

Genetic variation in LRRK2 associates with the susceptibility to Parkinson's disease, Crohn's disease, and mycobacteria infection. High expression of LRRK2 and its substrate Rab10 occurs in phagocytic cells in the immune system. In mouse and human primary macrophages, dendritic cells, and microglia-like cells, we find that Rab10 specifically regulates a specialized form of endocytosis known as macropinocytosis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

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Source

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Identifiers

PMID: 32853409
DOI: 10.15252/embj.2020104862
PMCID: PMC7560233

Genes

CCR5
EHBP1L1
CCL5
EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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