Mycobacterium tuberculosis Phagosome Maturation Arrest: Selective Targeting of PI3P‐Dependent Membrane Trafficking

Abstract excerpt

The ability of Mycobacterium tuberculosis to enter host macrophages, and reside in a phagosome, which does not mature into a phagolysosome, is central to the spread of tuberculosis and the associated pandemic involving billions of people worldwide. Tuberculosis can be viewed as a disease with a significant intracellular trafficking and organellar biogenesis component. Current understanding of the block in M....

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