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Article

Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest.

The EMBO journal - 15 Nov 2006

Kyei George B, Vergne Isabelle, Chua Jennifer, Roberts Esteban, Harris James, Junutula Jagath R, Deretic Vojo

Abstract excerpt

Mycobacterium tuberculosis arrests phagosomal maturation in infected macrophage, and, apart from health significance, provides a superb model system to dissect the phagolysosomal biogenesis pathway. Here, we demonstrate a critical role for the small GTPase Rab14 in maintaining mycobacterial phagosome maturation block. Four-dimensional microscopy showed that phagosomes containing live mycobacteria accumulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17082769
DOI: 10.1038/sj.emboj.7601407
PMCID: PMC1636625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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