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Article

<i>Coxiella burnetii</i> effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis

18 Nov 2013

Abstract excerpt

Successful macrophage colonization by Coxiella burnetii, the cause of human Q fever, requires pathogen-directed biogenesis of a large, growth-permissive parasitophorous vacuole (PV) with phagolysosomal characteristics. The vesicular trafficking pathways co-opted by C. burnetii for PV development are poorly defined; however, it is predicted that effector proteins delivered to the cytosol by a defective in...

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PMID: 24248335
DOI: 10.1073/pnas.1309195110

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