Article
[Childhood-onset systemic lupus erythematosus: polygenic or monogenic disorder?].
La Revue de medecine interne - 1 Apr 2013
Bader-Meunier B, Jeremiah N, Rieux-Laucat F
Abstract excerpt
Systemic lupus erythematosus (SLE) results from the complex interaction between genetic and environmental factors. It is usually thought that SLE results from the combined effect of variants in a large number of genes, and several genome whole association studies (GWAS) have identified a great number of single-nucleotide polymorphisms (SNP) associated with SLE. However, the loci identified so far can account for...
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