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Article

Characterization of gene-environment interactions by behavioral profiling of selectively bred rats: the effect of NMDA receptor inhibition and social isolation.

Behavioural brain research - 1 Mar 2013

Petrovszki Zita, Adam Gabor, Tuboly Gabor, Kekesi Gabriella, Benedek Gyorgy, Keri Szabolcs, Horvath Gyongyi

Abstract excerpt

Gene-environment interactions have an important role in the development of psychiatric disorders. To generate and validate a new substrain of rats with signs related to schizophrenia, we used selective breeding after postweaning social isolation and chronic ketamine treatment through several generations of animals and compared the subsequent strain to naive rats that were not genetically manipulated. We further...

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Identifiers

PMID: 23195116
DOI: 10.1016/j.bbr.2012.11.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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