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Article

Effects of SPAK knockout on sensorimotor gating, novelty exploration, and brain area-dependent expressions of NKCC1 and KCC2 in a mouse model of schizophrenia.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Aug 2015

Yang Sung-Sen, Huang Chuen-Lin, Chen Huei-E, Tung Che-Se, Shih Han-Peng, Liu Yia-Ping

Abstract excerpt

SPAK (Sterile 20/SPS1-related proline/alanine-rich kinase) is a protein kinase belonging to the mitogen-activated protein kinase (MAPK) superfamily that has been found to be extensively distributed across the body. The SPAK downstream substrates NKCC1 and KCC2 in the central nervous system are important in the interpretation of developmental mental disorders. The present study aimed to clarify the role of...

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PMID: 25797415
DOI: 10.1016/j.pnpbp.2015.03.007

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