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Article

Transgenerational consolidation of schizophrenia-relevant behavioral phenotypes reveals sex-specific trajectories and individual heterogeneity.

Experimental and molecular pathology - 1 Jun 2026

Horvath Gyongyi, Czimbalmos Olivér, Plesz Szonja B, Liszli Peter, Kekesi Gabriella, Braunitzer Gábor, Kőrösi Gábor

Abstract excerpt

Modeling schizophrenia in rodents is challenging because of the disorder's complexity and multifactorial etiology. This study aimed to elucidate the transgenerational consolidation of schizophrenia-relevant behavioral alterations in a triple-hit rat model (Lisket) developed on the behaviorally active Long Evans (LE). The Lisket line was established by combining post-weaning social isolation, repeated ketamine...

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Identifiers

PMID: 42140157
DOI: 10.1016/j.yexmp.2026.105051

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